#12: Individualized TMS Targeting in Schizophrenia using Bayesian Optimization Of NeuroStimulation

Speakers: (1) Dr. Lindsay Oliver (PhD, Neuroscience), Staff Scientist at the Centre for Addiction and Mental Health (CAMH) and Assistant Professor in the Department of Psychiatry at the University of Toronto
(2) Salim Mansour (BSc, Software Engineering), Research Methods Specialist at CAMH

Talk overview: Transcranial magnetic stimulation (TMS) is an innovative noninvasive therapeutic approach that uses a magnetic coil to stimulate specific areas of the brain. However, individual differences in brain structure and function can cause variations in treatment response. To address this, we developed BOONStim, an automated, end-to-end pipeline that generates personalized TMS coil positions using surface-based fMRI analytic tools and TMS electric field modelling.
In this presentation, Dr. Lindsay Oliver and Salim Mansour will discuss the background, development, and ongoing application of BOONStim, then showcase how it works in practice. We will walk through an example, from initial preprocessing steps (using tools including freeSurfer, fMRIPrep, and ciftify) to the methods for generating individualized treatment targets (using mri2mesh and Bayesian optimization) for use in Brainsight neuronavigation software.
Note: While the speakers will provide an overview of how to use BOONStim, they recommend exploring it further after the session. The team is happy to answer any questions, so feel free to reach out to them via email (lindsay.oliver@camh.ca and salim.mansour@camh.ca).

Publication DOI: 10.1016/j.brs.2025.01.020 BOONStim
Repo: https://github.com/tigrlab/boonstim