Mutations in the number of chromosomes can arise spontaneously by chromosome non-disjunction during meiosis. See how non-disjunction in meiosis I and meiosis II can result in aneuploidy and polyploidy.
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Image credits
https://en.wikipedia.org/wiki/Meiosis
https://commons.wikimedia.org/wiki/File:Mitotic_nondisjunction.png
https://jv.wikipedia.org/wiki/Poliploidi