Collagen Types, Collagen synthesis, Collagen disorders

📌 𝐅𝐨𝐥𝐥𝐨𝐰 𝐨𝐧 𝐈𝐧𝐬𝐭𝐚𝐠𝐫𝐚𝐦:- https://www.instagram.com/drgbhanuprakash Hello Everyone, To Access, The Notes Of this Session, Join Our Telegram Channel. We Will Post Notes After the session JOIN HERE:- https://t.me/bhanuprakashdr Subscribe To My Mailing List:- https://linktr.ee/DrGBhanuprakash Types of Collagen, Collagen synthesis, Collagen disorders Collagen is the most common type of fiber found in the ECM. There are at least 25 subtypes (don’t worry, we only need to know about four of those!), which vary in the specific amino acid sequences. Type I collagen is the most common among the collagen subtypes and makes up 90% of all the collagen in our body! It is found in bone, skin, tendons, ligaments, organ capsules, dermis, and even the dentin and cementum in our teeth. Its key function is to resist tension, which makes sense, right? You want the bones in your body, which are made of type I collagen, to be able to resist tension; otherwise you’d always be getting broken bones. In this transmission electron micrograph (TEM) image of collagen, we can see that the collagen fibers are very straight and not branched. Their “stripy” appearance is due to a complex, staggered arrangement of smaller molecules called tropocollagen. Type II collagen fibers are found primarily in hyaline cartilage matrix, but they are also present in the nucleus pulposus of vertebral discs and the vitreous body of the eye. Their primary function is to resist pressure. These fibers are very thin and not easily seen with hematoxylin and eosin (H&E) staining. In the hyaline cartilage in (high magnification), the matrix components—type II collagen fibers and glycosaminoglycans (GAGs)—blend together to give the matrix a smooth, glassy appearance. Type III collagen fibers are extremely fine and delicate. They form web-like networks that provide structural support inside hematopoietic organs like the bone marrow, spleen, and lymph nodes. They are also called reticulin (or reticular) fibers, derived from the Latin reticulum, meaning network. These fibers are invisible on regular H&E stains—but fortunately, they are argyrophilic (silver-loving), as you can see in this silver stain of hematopoietic tissue. Ehlers-Danlos syndrome (EDS) is a genetic disorder of connective tissues. Thirteen subtypes have been described. Vascular EDS is due to a genetic defect in transcribing or translating DNA or messenger RNA, respectively, which encodes type III collagen. Signs and symptoms of EDS include thin, easily bruised, fragile skin that can sometimes be excessively “stretchy” as well as hyperflexible joints that may be dislocated. It’s important to diagnose these patients before medical emergencies like rupture of the bowel or large arteries occur; type III collagen fibers surround smooth muscle cells of these tissues. Type IV collagen forms a meshwork of fibers and is found in the basal lamina of basement membranes. Its function is to support and anchor epithelial cells, as well as to aid filtration and act as a scaffold for cell migration. #collagen #collagenbenefits #collagentypes #collagensynthesis #type1collagen #collagendisorders #collagentype2 #collagentype3 #collagentype4 #collagentype1 #biochemistry #biochemistryvideos #medicalbiochemistry #mbbs #neetpg #fmge #usmlepreparation #usmle #nationalexittest #usmlestep1 #mbbslectures #nationalexitexam #usmlevideos #nmc #nmcreativelearning #nmcdraft2021 #nationalmedicalcommission