Timestamps:
00:00:00 🧬 Lipotoxicity and Hair Follicle Health
- Explains the role of peroxisome proliferator-activated receptor gamma (PPAR-gamma) in lipid metabolism and its dysfunction leading to lipotoxicity.
- Lipotoxicity leads to inflammation and tissue destruction.
- Examples of lipotoxicity effects in human diseases like non-alcoholic fatty liver disease, type 2 diabetes, and atherosclerosis.
00:02:18 💔 Lipotoxicity Related to Hair Loss Disorders
- Describes how lipotoxicity potentially links genetic and scarring alopecia through a shared pathway.
- Dysfunction of PPAR-gamma in hair follicles promotes lipotoxicity.
- Relationships with genetic sensitivity to dihydrotestosterone (DHT) and androgenetic alopecia.
00:05:37 ⚖️ Role of DHT and Sebaceous Glands
- Discusses the impact of DHT on sebaceous glands and sebum production.
- Links the overproduction of sebum to acne development, particularly in androgen-sensitive skin areas.
- Outlines potential treatments through drugs like topical clascoterone cream.
00:08:13 🧪 Mechanism of Action of Anti-Androgens
- Analyzes the action of drugs like clascoterone in inhibiting DHT and reducing sebum production.
- Mechanism involves blocking DHT from binding to androgen receptors in sebocytes.
- Addresses how this may treat conditions like acne and androgenetic alopecia.
00:11:35 🌿 PPAR-Gamma and Scarring Alopecia
- Highlights the potential role of PPAR-gamma agonists in treating scarring alopecia conditions.
- Deficiency in PPAR-gamma function can lead to hair follicle and sebaceous gland destruction.
- Genetic or environmental factors might trigger PPAR-gamma downregulation.
00:15:48 🔄 Interplay of Hormones and Hair Loss
- Evaluates potential hormonal influences on hair loss and lipid accumulation.
- DHEA's role as both an agonist and influencer of PPAR-gamma expression.
- Emphasizes the complexity of hormonal pathways in contributing to hair disorders.
00:23:29 🚨 Seborrheic Dermatitis and DHT
- Discusses how seborrheic dermatitis relates to DHT's activation of sebaceous glands.
- Highlights studies linking androgenetic alopecia with seborrheic dermatitis prevalence.
- Examines how DHT influences skin conditions like acne and seborrheic dermatitis.
Sources:
Harnchoowong, S., & Suchonwanit, P. (2017). PPAR-Γ agonists and their role in primary cicatricial alopecia. PPAR Research, 2017, 1–12. https://doi.org/10.1155/2017/2501248
Hebert, A., Thiboutot, D., Gold, L. S., Cartwright, M., Gerloni, M., Fragasso, E., & Mazzetti, A. (2020). Efficacy and safety of topical Clascoterone Cream, 1%, for treatment in patients with facial acne. JAMA Dermatology, 156(6), 621. https://doi.org/10.1001/jamadermatol.2020.0465
Makrantonaki, E., Ganceviciene, R., & Zouboulis, C. C. (2011). An update on the role of the sebaceous gland in the pathogenesis of acne. Dermato-Endocrinology, 3(1), 41–49. https://doi.org/10.4161/derm.3.1.13900
Miao, Y., Jing, J., Du, X., Mao, M., Yang, X., & Lv, Z. (2022). Frontal fibrosing alopecia: A review of disease pathogenesis. Frontiers in Medicine, 9. https://doi.org/10.3389/fmed.2022.911944
More than Just Oil Factories: A New Understanding of the Function of Sebaceous Glands. (n.d.). https://practicaldermatology.com/columns/clinical-focus-1/more-than-just-oil-factories-a-new-understanding-of-the-function-of-sebaceous-glands/23686/
Peterson, H., Kircik, L., & Armstrong, A. W. (2023). Individual article: Clascoterone Cream 1%: Mechanism of Action, Efficacy, and Safety of a Novel, First-in-Class topical antiandrogen therapy for acne. PubMed, 22(6), SF350992s7-SF350992s14. https://pubmed.ncbi.nlm.nih.gov/37276168
Senna, M. M., Peterson, E., Jozic, I., Chéret, J., & Paus, R. (2022). Frontiers in Lichen planopilaris and Frontal Fibrosing Alopecia Research: Pathobiology Progress and Translational Horizons. JID Innovations, 2(3), 100113. https://doi.org/10.1016/j.xjidi.2022.100113
Tabka, M., Mokni, S., Frioui, R., Fetoui, N., Ounallah, A., Sriha, B., Belajouza, C., & Denguezli, M. (2023). Rare and misdiagnosed entity fibrosing alopecia in a pattern distribution: A case report. Journal of Cosmetic Dermatology, 22(9), 2619–2621. https://doi.org/10.1111/jocd.15743
Thiboutot, D. (2004). Regulation of human sebaceous glands. Journal of Investigative Dermatology, 123(1), 1–12. https://doi.org/10.1111/j.1523-1747.2004.t01-2-.x
Wikipedia contributors. (2024, October 4). Peroxisome proliferator-activated receptor. Wikipedia. https://en.wikipedia.org/wiki/Peroxisome_proliferator-activated_receptor