Disclaimer: This video was made during the Afterbirth+ era, but all of these items are still very powerful and worth unlocking in Repentance. There are some minor differences in unlock methods and what certain items do, listed below.
- Restarting 7 times in a row now unlocks Scared Hearts instead of Half Soul Hearts, which are instead unlocked by defeating Mom's Heart 5 times
- The unlock requirements for Challenge #4 : Darkness Falls have been updated - you now also need to unlock Sacrificial Dagger by beating The Chest with Eve
- Challenges 4, 11 and 19 seem to be bugged and will randomly refuse to be unlocked
- Blank Card now only works with cards, not runes
- Deep Pockets now lets you hold a maximum of 999 pennies instead of its previous effect
(let me know about other differences I'm missing in the comments!)
Sections:
0:00 - Intro
1:09 - Azazel
2:44 - Eden
3:16 - Mom's Knife
4:09 - Blank Card
5:33 - The D6
6:48 - The Polaroid
7:42 - D20
9:19 - Bloody Penny
10:19 - Counterfeit Penny
11:35 - Swallowed Penny
13:30 - Jera
14:43 - Algiz
16:29 - Perthro
17:36 - Ansuz
18:21 - Dagaz
19:34 - Chaos Card
21:04 - Death's Touch
22:10 - Epic Fetus
26:08 - Outro
This video has been an insanely long time in the making (at least by my standards, since it took 3-4x longer than my previous guide), and I felt really tired after finally finishing it, so I won't start work on any new guide for at least a few weeks so that I don't burn out.
That said, if there is demand (especially around the Repentance release period), new guides will almost certainly come out.
Special thanks to Adrian Nuñez, who gave me the idea for this guide as well as a lot of encouraging words. Sorry for the 3-month wait, Adrian!
As before, feedback and constructive criticism is appreciated, and I'd love to hear what guides you think I should make next.
Chaos Card guide: https://www.youtube.com/watch?v=Qy1Y6G1gCyQ
Challenges on the Wiki: https://bindingofisaacrebirth.gamepedia.com/Challenges
Sources:
REEEEEE Sound Effect
https://www.youtube.com/watch?v=-HtNaVFpw4Q
THAT Crowd Gasp
https://www.youtube.com/watch?v=V5eaDhCVNJU
[Spoiler] reward for a [Spoiler] achievements isn't actually bad like some people assume (details in comments)
https://www.reddit.com/r/bindingofisaac/comments/5m0eir/spoiler_reward_for_a_spoiler_achievements_isnt/
Drum Roll - Gaming Sound Effect (HD)
https://www.youtube.com/watch?v=Ek56AgxwybI
Footage and editing by yours truly, images mostly from the Wiki (and some Twitch emotes)