Extending lifespan (lessons from the ITP)

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The Interventions Testing Program (ITP), funded by the National Institute on Aging, are testing different inventions to see if they prevent disease and extend lifespan in mice. The main goals are to provide preliminary evidence on compounds that have translational potential for human use to increase healthspan as well as to further understand the aging process through the protein targets of the compounds they identify as being effective. Since the initiation in 2003 and the testing of more than 40 compounds, 7 compounds have been identified to be extending the mouse lifespan significantly. However, this is to varying extents and some show sex-specific effects. So, in this video I will explain the lessons we can take from the ITPs work so far, take a look at their key principles, including their genetically heterogeneous mice, to ensure validity of
their results, and then the compounds that have been shown to extent lifespan, have no effect or are yet to be published.

TIMESTAMPS:
Intro - 00:00
What is the ITP? - 00:45
Key principles - 02:45
ITP experimental design - 05:40
7 compounds - 06:40
No extension/still being investigated - 13:30
Human translation? - 14:49
Outro - 14:00

REFERENCES
Mouse Phenome Database - https://phenome.jax.org/
ITP website - https://www.nia.nih.gov/research/dab/interventions-testing-program-itp
Nice review (The road ahead for health and lifespan interventions - https://doi.org/10.1016/j.arr.2020.101037
Latest ITP update - https://doi.org/10.1016/B978-0-12-815962-0.00010-X
Rapamycin dose-dep - https://doi.org/10.1111/acel.12194
Glycine paper - https://doi.org/10.1111/acel.12953
NDGA paper - Tezil, T., Chamoli, M., Ng, CP. et al. Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy. npj Aging Mech Dis 5, 7 (2019). https://doi.org/10.1038/s41514-019-0037-7

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