Function of Nephron in Kidney | Regulation of GFR | Renal System Physiology
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▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
(0:00-11:29)
Definition & basic structure of nephron; Glomerular Capillary Tuft, Visceral Epithelial Cells, Proximal Convoluted Tubules (PCT); Glomerulus & Bowman's Capsule; Glomerular Basement membrane (GBM).
(11:30-20:00)
Endothelial Cell structure in detail: fenestrations (perforations) & fenestrated capillaries
(20:01-33:20)
Glomerular Basement Membrane (GBM) structure in detail:
Lamina Densa & Lamina Rara; Collagen type IV detailed structure and Anti-GBM autoantibodies; Anti-GBM Glomerulonephritis & Good Pasteur Syndrome.
Mnemonics to remember types of Collagens; mention of Hereditary Nephritis.
(33:21-54:59)
Filtration function of Triple Layered Membrane:
Electronegativity of triple layered membrane; its significance as 'charge barrier' in filtration.
Filtration slits in foot processes of visceral epithelial cells; their significance as 'size barrier'.
Filtration of Plasma Proteins through the triple layer; significance of negative charge in repelling Albumin; clinical co-relate with Minimal Change Glomerulonephritis/Glomerulopathy (MCG).
(55:00-57:42)
Mesangial Cells; influence on glomerular filtration.
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