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Gene Set Enrichment Analysis (+ R tutorial)

LiquidBrain Bioinformatics 54,510 lượt xem 3 years ago
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Enrichment analysis is very common in the Omics study. Did you know, with the same result from the Differential Expression Analysis, we can obtain two different types of enrichment results. This video guides you on the how and why performing them.

*Apologize for the bad audio background*

Useful links:
1. ClusterProfiler tutorial book
http://yulab-smu.top/clusterProfiler-book/index.html
2. Harvard Chan Bioinformatics Core (HBC) learning hub
https://hbctraining.github.io/DGE_workshop/lessons/09_functional_analysis.html
3. GSEA original paper
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., ... & Mesirov, J. P. (2005). Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences, 102(43), 15545-15550.

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