Professional contract killer Duke Togo—codenamed "Golgo 13"—is hired to assassinate Robert Dawson, the son of oil baron Leonard Dawson and the heir of Dawson Enterprises, and succeeds. Later, after accomplishing a hit on a powerful crime boss in Sicily named Dr. Z, Golgo is suddenly attacked by the U.S. Military and CIA. His local contact, a clockmaker, is also murdered by a genetically enhanced supersoldier named Snake. Aided by the Pentagon, the FBI, and the CIA, Dawson has become determined to kill Golgo and avenge his son's death.