Gru (voiced by Steve Carell) confronts his longtime rival, Maxime Le Mal (voiced by Will Ferrell), who has transformed into a formidable cockroach-human hybrid.
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Gru, Lucy, Margo, Edith, and Agnes welcome a new member to the family, Gru Jr., who is intent on tormenting his dad. Gru faces a new nemesis in Maxime Le Mal and his girlfriend Valentina, and the family is forced to go on the run.