In this Metabolic Classroom lecture, Dr. Bikman delves into the fascinating metabolic process of autophagy, the body’s natural recycling system that maintains cellular health by breaking down and reusing damaged components.
Ben explains how autophagy is essential for replacing malfunctioning organelles and proteins, thereby preventing diseases such as neurodegenerative disorders, cardiovascular conditions, and even some cancers. Autophagy also plays a crucial role in energy production during nutrient deprivation, highlighting its importance for survival and optimal cellular function.
Dr. Bikman also discusses the relationship between autophagy and metabolic health, emphasizing how impaired autophagic activity in adipose tissue contributes to inflammation and insulin resistance in obesity. He explores its role in longevity, citing evidence that enhanced autophagy can improve health span and lifespan in animal studies.
Additionally, Ben examines how factors like insulin, nutrient availability, and diets such as ketogenic diets regulate autophagy, with ketones having a direct effect on boosting this process.
Throughout the lecture, Dr. Bikman underscores the need for balance in autophagy, warning against excessive or constant activation, whether through pharmacological means like rapamycin or mismanaged dietary habits, advocating instead for natural regulation via nutrient signals.
Show Notes/References:
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Timestamps:
01:44 - What is Autophagy? A Cellular Perspective
05:28 - Role of Autophagy in Energy Production During Fasting
07:41 - Autophagy’s Connection to Obesity and Metabolic Health
12:05 - Autophagy and Longevity: Insights from Research
14:34 - Rapamycin, mTOR, and the Risks of Pharmacological Interventions
17:07 - Insulin’s Role in Autophagy Regulation
20:00 - How Low-Carb and Ketogenic Diets Enhance Autophagy
24:10 - Balancing Anabolism and Catabolism for Optimal Health
26:35 - Conclusion: The Natural Regulation of Autophagy
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Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10)
Ben’s favorite electrolytes (and more): https://redmond.life (discount: BEN15)
Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20)
Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15)
Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15)
Ben’s favorite exogenous ketone: https://www.americanketone.com (discount: Ben10)
Other products Ben likes: https://www.amazon.com/shop/benbikmanphd
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