A talk by Jonathan Blow at GDC Europe 2011 about truth in game design.
Description from the GDC Vault website:
We illustrate that games, being algorithmic systems implemented on computers, are biased toward revealing truth, so long as we do not quash the truth in order to force our own high-level wishes into the design. We can use games as instruments, like telescopes or electron microscopes, to observe aspects of the universe that we would not normally have access to.