Cancer Biology Course
https://www.abdalfttah-academy.com/en/courses/1
Welcome to Lecture 4 of the Protein Translation Course with Mohmed Abdalfattah, PhD Candidate at the Faculty of Medicine, Universidad Autónoma de Madrid.
In this lecture, we explore the essential first step in translation: tRNA charging. This highly accurate process ensures that each tRNA is loaded with the correct amino acid. You'll learn:
- What tRNA charging (aminoacylation) is and why it's essential before translation
- The role of aminoacyl-tRNA synthetases and how they recognize specific tRNAs
- How charging ensures translation fidelity and protects the genetic code
- The step-by-step mechanism of amino acid activation and transfer to tRNA
- Why mischarging can lead to errors in protein synthesis and even alter the genetic message
This lecture highlights how enzymes act as gatekeepers of the genetic code and how molecular precision is maintained at every step.
Stay tuned for Lecture 5, where we will dive into initiation and the ribosomal decoding process.
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