What is MDMA, really? In this deep dive, we explore the science behind MDMA (3,4-methylenedioxymethamphetamine), otherwise known as Molly or Ecstasy (XTC). We dive deep into the mechanism of action (neuroscience) and provide lots of scientific information regarding depletion of serotonin and neurotoxicity. We also explore its current medical research in psychedelic assisted therapy, and the real risks you need to know. From how it affects your brain and body to its therapeutic potential in treating PTSD and beyond, we break it all down using science—not hype.
Timestamps:
Intro: 00:00
History/Background: 00:49
Mechanism of Action: 03:29
Serotonin Depletion & Neurotoxicity: 07:35
Researched Benefits: 12:25
Expected Effects: 15:00
Risks & Side Effects: 17:00
Route of Administration, Dosing, Duration: 22:15
Drug-Drug Interactions: 24:15
Half-Life & Excretion Time: 26:45
Trip Time Essentials is all about delivering scientifically accurate information, tips and tricks, safety advice, and other tools and useful information regarding the use of psychedelics. We explore dose ranges, duration, effects, visuals to expect, mechanism of action (neuroscience), as well as supplements like the Pre-Trip product that can help alleviate common side effects.
---------------------------------------------------------------------------------------
Please Like, Comment, Subscribe, Share, and Watch some more videos!
---------------------------------------------------------------------------------------
Trip Time Essentials store: https://www.triptimeessentials.com/
Golden Facilitator (Aaron's Facilitating Business): https://goldenfacilitator.com/
Psilocybin Deep Dive: https://youtu.be/5wF_tJgCiaY?si=FMCNmG1ILsj8Za6J
Legal Psychedelics Video: https://youtu.be/Ji942fTMn3I?si=N18GA2RoBNIPaMXI
---------------------------------------------------------------------------------------
Research Studies & Resources:
1. A Review of 3,4-methylenedioxymethamphetamine (MDMA)-Assisted Psychotherapy. Frontiers in Psychiatry. 2019 doi: https://doi.org/10.3389/fpsyt.2019.00138
2. Striatal serotonin is depleted in brain of a human MDMA (Ecstasy) user. Neurology. 2000;doi: https://doi.org/10.1212/wnl.55.2.294
3. Long-term neuronal damage and recovery after a single dose of MDMA: expression and distribution of serotonin transporter in the rat brain. 2010; https://pubmed.ncbi.nlm.nih.gov/20962361/
4. Single dose of MDMA causes extensive decrement of serotoninergic fibre density without blockage of the fast axonal transport in Dark Agouti rat brain and spinal cord. 2007; doi: https://doi.org/10.1111/j.1365-2990.2006.00790.x
5. Concurrent Inhibition of Vesicular Monoamine Transporter 2 Does Not Protect Against 3,4-Methylenedioxymethamphetamine (Ecstasy) Induced Neurotoxicity. 2019;170(1):157-166. doi: https://doi.org/10.1093/toxsci/kfz085
6. Methylenedioxymethamphetamine (MDMA): Serotonergic and dopaminergic mechanisms related to its use and misuse. Journal of Neurochemistry. 2021; doi: https://doi.org/10.1111/jnc.15348
7. The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”). Pharmacological Reviews. 2003; doi: https://doi.org/10.1124/pr.55.3.3
8. MDMA From Rave Drug to Rave Reviews in Clinical Trials. Published January 12, 2023. https://www.caymanchem.com/news/mdma-from-rave-drug-to-rave-reviews-in-clinical-trials
9. Retraction Note: MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials. Psychopharmacology. Published online August 10, 2024. doi: https://doi.org/10.1007/s00213-024-06666-x
10. Couple Therapy With MDMA—Proposed Pathways of Action. Frontiers in Psychology. 2021; doi: https://doi.org/10.3389/fpsyg.2021.733456
11. Facing death, returning to life: A qualitative analysis of MDMA-assisted therapy for anxiety associated with life-threatening illness. Frontiers in Psychiatry. 2022; doi: https://doi.org/10.3389/fpsyt.2022.944849
12. The effects of MDMA-assisted therapy on alcohol and substance use in a phase 3 trial for treatment of severe PTSD. Drug and Alcohol Dependence. 2022; doi: https://doi.org/10.1016/j.drugalcdep.2022.109356
13. Reduction in social anxiety after MDMA-assisted psychotherapy with autistic adults: a randomized, double-blind, placebo-controlled pilot study. Psychopharmacology. 2018; doi: https://doi.org/10.1007/s00213-018-5010-9
14. Cardiac effects of MDMA on the metabolic profile determined with 1H-magnetic resonance spectroscopy in the rat. 2009;. doi:https://doi.org/10.1002/nbm.1352
15. Midomafetamine. go.drugbank.com. https://go.drugbank.com/drugs/DB01454
---------------------------------------------------------------------------------------
Intro Music Credits: Song: Last Summer Composer: Ikson Website: / ikson License: Free To Use YouTube license youtube-free Music powered by BreakingCopyright: https://breakingcopyright.com