MIT Computational Biology: Genomes, Networks, Evolution, Health
Prof. Manolis Kellis
http://compbio.mit.edu/6.047/
Fall 2018
Lecture 15 - eQTLs
1. Motivations for mapping regulatory variants
2. Ex: Methylation QTLs in Alzheimer’s Disease
3. eQTL conceptual frameworks
4. eQTL discovery: methodologies
5. Insights on eQTL function and biology
- eQTL prevalence and impact
- eQTL positioning
- Reproducibility
- Tissue-specificity
- Gene annotation
- Co-regulation
- Trans-acting eQTL
- Disease-enrichment
- Directionality
- Disease-relevance
6. Allele-specific analysis
7. Mediation analysis & Bayesian inference
Slides for Lecture 15:
https://stellar.mit.edu/S/course/6/fa18/6.047/courseMaterial/topics/topic2/lectureNotes/Lecture15_eQTLs/Lecture15_eQTLs_6up.pdf