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. Nitric oxide is a potent vasodilator in the cardiovascular system having the role of regulation of blood pressure and vascular tone.
Dr. Mobeen Syed, in this video, explains the mechanism of action of nitric oxide and the factors that trigger its release.
Nitric oxide is released from the endothelium of the blood vessels by multiple factors, for example, increased blood flow, vasoactive amines, histamine, prostacyclins, etc
Nitric oxide triggers soluble guanylate cyclase, and increased cGMP causes the increased activity of myosin light chain-phosphatase.
This enzyme causes the relaxation of blood vessels.
In atherosclerosis, there is a reduction in the release of nitric oxide from the endothelium of the blood vessels. It causes reduced cGMP and reduced myosin light chain-phosphatase activity. Blood vessel contraction occurs by the action of myosin light chain kinase.
The following topics have discussed in the full video:
* Mechanism of action of Nitric oxide
* Multiple causes of nitric oxide release
* Vasodilation effect of nitric oxide
* Role of nitric oxide in atherosclerosis
* Role of angiotensin II in nitric oxide release
* Role of sildenafil in nitric oxide release ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.