In this video, we will explore the positional system of the brain - hippocampal place cells. We will see how it relates to contextual memory and mapping of more abstract features
OUTLINE:
00:00 Introduction
00:53 Hippocampus
1:27 Discovery of place cells
2:56 3D navigation
3:51 Role of place cells
4:11 Virtual reality experiment
7:47 Remapping
11:17 Mapping of non-spatial dimension
13:36 Conclusion
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REFERENCES:
1) Anderson, M.I., Jeffery, K.J., 2003. Heterogeneous Modulation of Place Cell Firing by Changes in Context. J. Neurosci. 23, 8827–8835. https://doi.org/10.1523/JNEUROSCI.23-26-08827.2003
2) Aronov, D., Nevers, R., Tank, D.W., 2017. Mapping of a non-spatial dimension by the hippocampal–entorhinal circuit. Nature 543, 719–722. https://doi.org/10.1038/nature21692
3) Bostock, E., Muller, R.U., Kubie, J.L., 1991. Experience-dependent modifications of hippocampal place cell firing. Hippocampus 1, 193–205. https://doi.org/10.1002/hipo.450010207
4) Christopher D. Harvey, Forrest Collman, Daniel A. Dombeck, David W. Tank, 2009. Intracellular dynamics of hippocampal place cells during virtual navigation. Nature. https://doi.org/10.1038/nature08499
5) Grieves, R.M., Jedidi-Ayoub, S., Mishchanchuk, K., Liu, A., Renaudineau, S., Jeffery, K.J., 2020. The place-cell representation of volumetric space in rats. Nat Commun 11, 789. https://doi.org/10.1038/s41467-020-14611-7
6) Jeffery, K.J., 2011. Place Cells, Grid Cells, Attractors, and Remapping. Neural Plasticity 2011, 1–11. https://doi.org/10.1155/2011/182602
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8) Laura Lee Colgin, Edvard I. Moser, May-Britt Moser, 2008. Understanding memory through hippocampal remapping. Trends in Neurosciences. https://doi.org/10.1016/j.tins.2008.06.008
9) Meredith Minear, Tesalee K. Sensibaugh, 2020. Neuroscience of Navigation. https://doi.org/10.1002/9781119458555.ch53
10) Moita, M.A.P., 2004. Putting Fear in Its Place: Remapping of Hippocampal Place Cells during Fear Conditioning. Journal of Neuroscience 24, 7015–7023. https://doi.org/10.1523/JNEUROSCI.5492-03.2004
11) O’Keefe, J., Burgess, N., 1996. Geometric determinants of the place fields of hippocampal neurons. Nature 381, 425–428. https://doi.org/10.1038/381425a0
12) Robinson, N.T.M., Descamps, L.A.L., Russell, L.E., Buchholz, M.O., Bicknell, B.A., Antonov, G.K., Lau, J.Y.N., Nutbrown, R., Schmidt-Hieber, C., Häusser, M., 2020. Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior. Cell 183, 1586-1599.e10. https://doi.org/10.1016/j.cell.2020.09.061
13) Wohlgemuth, M.J., Yu, C., Moss, C.F., 2018. 3D Hippocampal Place Field Dynamics in Free-Flying Echolocating Bats. Front. Cell. Neurosci. 12, 270. https://doi.org/10.3389/fncel.2018.00270
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