Why not? Try it out! It's a lot of fun.
I ran the guitar into the Behringer Cat and did some slight filtering there. From there it goes to the EXT in of the Model D mixer section with the mixer and filter running hot and distorting. There's a boost pedal on before the synthesizers for a stronger signal but the guitar does not distort before it hits the Model D which provides all of the grit. UAFX Golden Reverberator for reverb and Starlight Echo Station for delay as usual. The delay is running 100% wet and that's why it looks like the video is out of sync. You're only hearing the delay signal.
The slight droning bass in the background is coming from the Cat.