Dr. Michael Silber, a Professor of Neurology at the Mayo Clinic College of Medicine in Rochester, MN, shares his article appearing in an upcoming issue of Mayo Clinic Proceedings, where he provides an update on management of restless legs syndrome. He discusses iron therapy, first line treatment of chronic persistent restless legs, and the use of opioids for refractory disease. Newly added information addresses the treatment of restless legs syndrome in pregnancy and childhood. Available at: https://mayocl.in/2KhvZgo