The relationship between Fred Sanford and Aunt Esther was characterized by constant bickering, arguments, and insults. Fred often referred to Esther as "Ugly" or "Queen Esther," mocking her appearance and personality. In return, Aunt Esther would insult Fred and accuse him of various wrongdoings. Despite their constant quarreling, there was an underlying affection between the characters. The dynamic between Fred and Aunt Esther provided much of the comedic tension in the show, and their interactions became a signature element of "Sanford and Son."