In this episode Dr Nirala Jacobi is in conversation with Dr Christopher Shade. Dr Shade is the CEO and founder of Quicksilver Scientific, a lab that specialises in the environmental, biological, and analytical chemistry of mercury and all of its forms, and its interaction with sulphur compounds, particularly glutathione, and its enzyme systems.
Dr Jacobi met Dr Shade at the Bioceuticals Research Symposium in Sydney, 2017, and was riveted by his presentation on detoxification.
Topics discussed in this episode include:
● The liver, gallbladder, and GI connection, and how to align them so as to clear gastrointestinal issues.
● How failure to move bile is at the heart of detox reactions
○ Bile as a detergent in the small intestine and how bile can be a core issue in SIBO.
● Bile acid destruction and fat malabsorption in SIBO.
● Emunctories and what this means.
○ Drainage areas and how the extracellular space is cleared.
●Metal binder for the GI tract that is far better than chlorella - IMD microsilica
● Toxin conjugates and their interaction with bile salts.
●Phosphatidylcholine (PC), its requirement to fluidise the bile, and choline’s relationship to cholestasis.
● Lipopolysaccharide (LPS) endotoxins from leaky gut (from SIBO) creating inflammation in the hepatocytes and the flow on effects from this.
●Phase 3 detoxification - The role of bile flow in lessening detoxification reactions through lowering toxic conjugate buildup in the blood, and instead moving them through the proper elimination channels.
● The importance of addressing emunctories in treating skin conditions.
● How LPS impairs phase 3 in the liver.
● Neurological consequences of leaky gut, SIBO, and of a backfiring liver.