Jessica Jones, a former flying costumed superhero "Jewel/Knightress" with a hard punch, current booze-loving super private investigator and girlfriend, later wife of Luke Cage. She adventures alone, with her spouse, her best friend Carol Danvers (aka ms/cpt Marvel) or with various superheroes and teams New Avengers, Mighty Avengers and Defenders.
#20 Big strong henchman to many different villains, fought fiercely against JJ when he served #HM1.
#19 Strange scientist who can create teleportation portals, Abducted JJ when he was acting as #5's henchman.
#18 A powerful enemy of the X-men, He stole the DNA of JJ's daughter Danielle and tried to trade it on the black market in the story "Adamantium Agenda"
#17 A robot expert who tried to take over the city with his robot army and was confronted by Luke, JJ and his friends in the story "Luke Cage: Gang War".
#16 Mutant assassin and psychopath, got into a fight with JJ and Luke when they were bodyguards. Later was JJ's crazy cellmate when JJ was undercover in prison.
#15 the time-travelling super-villain, he actually killed JJ while he was on the young Avengers' journey. His younger version, Iron Lad, changed the timeline and brought his victims back from the dead.
#14 a businessman who looked into the "Beyond", outside the multiverse and lost face but gained tremendous superpowers and became a "debased unit" Beyonder with plans for world conquest. He encountered Luke and JJ, teleported them into outer space which nearly killed them without the help of the Mighty Avengers.
#13 Lenny Sirkes, wreaking havoc with his supershark armour. An enemy of Luke and JJ.
#12 A crime boss, usually an enemy of Daredevil and JJ's villain when she was "Knightress". She and Luke met for the first time when they were both chasing him.
#11 The demonic crime boss and his super-villain gang became a threat to JJ when she was in the New Avenger and later also in the Defenders.
#10 A drug lord who manufactures and sells super drugs. He kidnapped and exploited Spider-girl Mattie, who was tracked down and released by JJ.
#9 When a young douchebag gets the power of Sentry. Homelander-style Marvel villain who craves respect and more power. JJ's newest foe she's managed to stop.
#8 a Mad scientist and Spidey's archfoe. JJ met his best friend Carol Danvers while fighting him. Later he as the Superior Spider-Man challenged Luke's and JJ's leadership in the Mighty Avengers and he was also resurrecting #1 when he and Kingpin wanted to use the power of #1 for their own power play.
#7 a young man who lusted after his girlfriend's superpowers, and after gaining them, he split into two sides - the good side and the murderous evil side, killing many superheroes and the good side bringing them back to life. With the help of Elsa Bloodstone, JJ managed to stop this duality.
#6 Psychopathic industrialist and Spidey's archfoe. JJ and Ben Urich revealed his secret identity which led to him attacking them and almost killing JJ's unborn child. He has also later threatened to kill JJ's child Danielle.
#5 A cunning businesswoman who chases superheroes, sworn enemy of Carol Danvers who tried to win JJ over and betray her superfriend.
#4 Benjamin Killgrave, #1's son. He gained similar powers from his father's DNA and used them to control his siblings, the Purple Children, and also JJ.
#3 JJ's evil counterpart from another universe, with her superhero name but she is a powerful energy and force manipulator. She travels from universe to universe collecting her own counterparts for own super-villain team.
#2 the main villain of the Defenders era, archenemy of his spouse Luke Cage and therefore a major enemy for JJ as well. He tried to kill JJ with her husband out of the way as he tried to rise to the top of crime using superdrug to help him.
#HM1 Evil businessman who tried to use JJ to find out the identity of Cpt America.
#HM2 Supersoldier and mainly Cpt America's enemy who appeared on JJ TV show as her enemy.
#HM3 Spidey foe, the first enemy JJ faced and defeated.
#HM4 Nuhuman, who couldn't control her powers which caused her to turn into a dragon and Kate Bishop and JJ to become her targets.
#HM5 Skrull, posing as Jarvis, betrayed JJ's trust and stole his child Danielle.
#1 When ranks 2-6 are tight the number one is clear. JJ's archenemy, a powerful mind controller and hypnotist who ended her youthful superhero career by abusing her for 8 months, eventually putting her on the attack against other superheroes, an incident from which JJ has never recovered and he comes back from time to time to haunt her again.