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Xenobiotic Metabolism || Detoxification - Phase I Reactions || Biochemistry || Part 01

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Xenobiotic Metabolism and Detoxification - This video is on the Metabolism of Xenobiotics , Phase 1 Reactions of Detoxifications with the role of Cytochrome P450 along with NEET PG MCQs. Definition of Xenobiotics - 01:10 minutes Detoxification and Biotransformation - 01:45 minutes Mechanism of Detoxification of Xenobiotic - 02:33 minutes Phase 1 and Phase 2 Reactions - 03:02 minutes Cytochrome P450 - 03:51 minutes Phase 1 reactions Oxidation - 06:34 minutes Reductions - 08:37 minutes Hydrolysis - 09:11 minutes NEET PG MCQs - 10:14 minutes Certain unwanted and harmful chemical agents may enter the human body through various routes such as inhalation, ingestion, skin contact, etc. Most of these foreign compounds are subjected to metabolism (chemical alteration) in the human body. In the past the metabolic processes that lead to the disposition of foreign compounds have been referred to as detoxification mechanisms. MECHANISM OF DETOXIFICATION OF XENOBIOTICS The liver is the principal organ responsible for detoxification of xenobiotics. The pathways for hepatic detoxification include either: 1. Oxidation 2. Reduction 3. Hydrolysis 4. Conjugation 5. Some combinations of all these metabolic reactions However, the term is not always appropriate because the detoxified products are sometimes more toxic than the original substance. Biotransformation has been suggested as a preferable term These foreign compounds are known as xenobiotics (Greek, Xenos = stranger). #xenobioticmetabolism #detoxification #phase1reactions #NEETPG #NEETPGbiochemistry #biochemistrybasicsbyDrAmit #USMLE

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