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Your thymus isn't talked about much, but this small organ in your upper chest is a key component of your immune system that is solely responsible for the essential "education" of the immune cells that protect your body from invaders. Through this action it also affects levels of inflammation (an immune-mediated process). It's also interesting to note that most of us end up dying of an immune-related dysfunction - even cardiovascular disease, as Dr. Greg Fahy points out in this New Frontiers podcast, is often caused by atherosclerosis driven by underlying chronic inflammation.
I was thrilled to finally sit down with Dr. Fahy, whose groundbreaking work in aging has truly reshaped our understanding of what’s possible. His 2019 TRIIM study, showing clear epigenetic age reversal through thymus regeneration, was an absolute game-changer. The thinking prior to that was that epigenetic age reversal was not possible! It was exciting to read his publication as we were in the midst of our own original clinical trial. I'm sure you'll enjoy his recounting of that adventure and just how he's rejuvenating thymic function, the rationale for targeting immune rejuvenation, and the trial extensions he's currently working on now, in this episode of New Frontiers. - DrKF
Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources. ~DrKF
*GUEST DETAILS*
*Greg Fahy, PhD*
Chief Scientific Officer and Co-founder Intervene Immune
Email: fahy@interveneimmune.com
Dr. Greg Fahy received his Ph.D. in Pharmacology and Cryobiology from the Medical College of Georgia in 1977. A world-renowned cryobiologist, Dr. Fahy is the chief science officer and co-founder of Intervene Immune, where he leads groundbreaking research on thymus regeneration and combating age-related immune decline. He designed and led the TRIIM trial, the first to demonstrate both thymus rejuvenation and the reversal of human epigenetic age. His work has been pivotal in advancing aging research, resulting in successful follow-up trials like TRIIM-XA, and further planned studies aimed at refining and expanding these innovative treatments.
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*SHOW NOTES*
Intervene Immune https://interveneimmune.com/
Reversal of epigenetic aging and immunosenescent trends in humans https://tinyurl.com/55dhx453
TRIIM-X Trial: Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial https://tinyurl.com/y65cu33p
The Future of Aging: Pathways to Human Life Extension https://tinyurl.com/3hmbx29c
Steve Horvath, PhD, ScD https://tinyurl.com/3f4jww7j
Bobby Brooke https://tinyurl.com/3f4jww7j
Science: TRIIM trial to target thymus https://tinyurl.com/4s79zkzv
Nature: First hint that body’s ‘biological age’ can be reversed https://tinyurl.com/nfz9ruy7
Research and Resources from Intervene Immune https://tinyurl.com/ymu2ffat
TAME Trial https://tinyurl.com/yc3ce32b
Study: Apparent induction of partial thymic regeneration in a normal human subject: a case report
Apparent induction of partial thymic regeneration in a normal human subject: a case report https://tinyurl.com/yt7b8484
Study: Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls
Can people with type 2 diabetes live longer than those without? A comparison of mortality… https://tinyurl.com/4thfsrrr
*NEW FRONTIERS RESOURCES*
Blog: New and Notable Studies Using Epigenetic Biological Age Clocks
Podcast: Decoding Aging: The Science Of Cellular Rejuvenation With Dr. Vittorio Sebastiano
Podcast: AI, Digital Twins, and the Future of Personalized Medicine Interventions with Dr. Nathan Price
Interview: Past, Present, and Future of “Biological Aging” with Dr. Fitzgerald
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