In this video, we uncover the long-term and often irreversible effects of antipsychotic drugs, including brain volume loss, tardive dyskinesia, and cognitive decline.
Most doctors don't discuss these risks in detail, and patients are left unaware of the potential damage caused by these medications.
We’ll explore the evidence from both animal and human studies, explain how these medications affect your brain, and discuss what you can do to mitigate the risks.
If you or a loved one is on antipsychotics, this information is essential to understand the potential long-term consequences.
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🔗 LINKS MENTIONED
- Dorph-Petersen KA, Pierri JN, Perel JM, et al. (2005). The influence of chronic exposure to antipsychotic medications on brain size before and after tissue fixation: A comparison of haloperidol and olanzapine in macaque monkeys. Neuropsychopharmacology, 30, 1649–1661.**
- Fusar-Poli P, Smieskova R, Kempton MJ, Ho BC, Andreasen NC, Borgwardt S. Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies. Neurosci Biobehav Rev. 2013 Sep;37(8):1680-91. doi: 10.1016/j.neubiorev.2013.06.001. Epub 2013 Jun 14. PMID: 23769814; PMCID: PMC3964856.
- Wu JQ, Chen DC, Xiu MH, Tan YL, Yang FD, Kosten TR, Zhang XY. Tardive dyskinesia is associated with greater cognitive impairment in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Oct 1;46:71-7. doi: 10.1016/j.pnpbp.2013.06.013. Epub 2013 Jul 1. PMID: 23827756.
- https://www.psychiatrictimes.com/view/tardive-dyskinesia-facts-and-figures
- Moncrieff J, Leo J. A systematic review of the effects of antipsychotic drugs on brain volume. Psychol Med. 2010 Sep;40(9):1409-22. doi: 10.1017/S0033291709992297. Epub 2010 Jan 20. PMID: 20085668.
Timestamps:
05:05 Brain Shrinkage and Its Implications
10:04 Movement Disorders: Tardive Dyskinesia Explained
15:11 Cognitive Decline and Long-Term Effects
16:33 Preventative Measures and Alternatives
‼️ DISCLAIMER: All the information on this channel is for educational and/or entertainment purposes and not intended to be specific/personal medical advice from me to you. Watching the videos, or getting answers to comments/question, does not establish a doctor-patient relationship. If you have your own doctor, these videos can maybe help you prepare for your discussion with him. We do our best to spread awareness with these videos, but for legal reasons we can’t answer health questions in the comments. If you leave questions, we’ll make videos about common questions in the future! If we catch incorrect health information, hate speech, illegal solicitation of drugs in the comments, we will remove them.