Foldit is a citizen science video game in which players tackle a variety of
complex biochemistry puzzles. Here, we describe a new series of puzzles
in which Foldit players improve the accuracy of the public repository of
experimental protein structure models, the Protein Data Bank (PDB).
Analyzing the results of these puzzles showed that the Foldit players were
able to considerably improve the deposited structures and thus, in most
cases, improved the output of the automated PDB-REDO refinement
pipeline. These improved structures are now being hosted at PDB-REDO.
These efforts highlight the continued need for the engagement of the lay
population in science.